- Ryan Eggold as Dr. Max Goodwin
- Janet Montgomery as Dr. Lauren Bloom
- Freema Agyeman as Dr. Helen Sharpe
- Jocko Sims as Dr. Floyd Reynolds
- Tyler Labine as Dr. Iggy Frome
- Anupam Kher as Dr. Vijay Kapoor
- The episode was originally supposed to be called "Revival", however, it was renamed to "Anthropocene".